SGLT2 Inhibitors Can Support Weight Loss, Cut back Fats Mass in Individuals with Sort 2 Diabetes


A scientific evaluation and meta-analysis is offering perception into the consequences of SGLT2 inhibitor use on physique composition in individuals with sort 2 diabetes.

Outcomes of the examine, which included knowledge from greater than a dozen research, element the optimistic results of SGLT2 inhibitor use on physique weight, BMI, waist circumference, and fats mass, but additionally make clear the potential unfavorable impression on lean mass.

“The spotlight of this meta-analysis is to verify not solely the benefits of SGLT2 inhibitors in enhancing physique composition, resembling weight reduction, BMI, waist circumference, visceral fats space, subcutaneous fats space, share physique fats, and fats mass discount, but additionally the antagonistic results of those medicine on muscle mass discount,” wrote investigators.

Lately, few, if any, therapeutic areas in cardiometabolic well being have seen a revolution in use as hypoglycemic brokers. As SGLT2 inhibitors have stolen headlines for his or her cardiorenal protecting advantages, GLP-1 receptor agonists have seen their position increase into weight administration exterior of diabetes. Though reported in trials, many questions stay surrounding the potential magnitude of weight reduction and results on composition of SGLT2 inhibitor use.

Citing this, and an curiosity in exploring a possible affiliation with elevated threat of sarcopenia, a group from the Cangzhou Central Hospital designed the current systematic evaluation and meta-analysis of randomized scientific trials inspecting SGLT2 inhibitor use in individuals with sort 2 diabetes. Performing a search of the PubMed, Cochrane Library, Embase, and Net of Science databases for randomized scientific trials inspecting SGLT2 inhibitor use revealed from 2013-2022, investigators recognized 18 research with a complete of 1430 contributors for inclusion. Among the many research, 3 examined canagliflozin, 8 examined dapagliflozin, 3 examined empagliflozin, and 4 examined ipragliflozin.

Outcomes of curiosity for the investigators’ analyses included adjustments in physique weight, BMI, waist circumference, share physique fats, fats mass, muscle mass, visceral fats space, subcutaneous fats space, lean mass, and skeletal muscle mass. Investigators identified outcomes have been in contrast by weight imply distinction (WMD).

In 14 randomized scientific trials reporting physique weight, outcomes indicated use of SGLT2 inhibitors was related to considerably decreased physique weight relative to the trials’ comparator brokers (WMD, -2.73 kg [95% CI , -3.32 to -2.13]; P <.00001), with investigators reporting low heterogeneity between research (I2=33%), In 7 trials reporting BMI, use of SGLT2 inhibitors was related to considerably decreased BMI relative to the trials’ comparator brokers.

Additional evaluation revealed use of ASGLT2 inhibitors was related to reductions in methods circumference (WMD, -2.20 cm [95% CI, -3.81 to -0.58]; P=.008), visceral fats space (WMD, -14.79 cm2 [95%CI, -24.65 to -4.93] P=.003), subcutaneous fats space (WMD, -23.27 cm2, 95% CI:-46. 44 to -0.11]; P=.05), fats mass (WMD, -1.16 kg [95%CI, -2.01 to -0.31]; P= .008), share physique fats (WMD, -1.50% [95% CI, -2.12 to -0.87]; P <.00001). Investigators additionally identified use of SGLT2 inhibitors was related to statistically important decreases in lean mass (WMD, -0.76 kg [95% CI, -1.53 to 0.01]; P=.05) and skeletal muscle mass (WMD, -1.01 kg [95% CI, -1.91 to -0.11]; P=.03).

“Till extra proof is obtained to assist that SGLT-2 inhibitors enhance the danger of sarcopenia, not solely the profit on physique composition, but additionally the antagonistic results of the discount on muscle mass by SGLT-2 inhibitors in T2DM must be thought-about,” concluded investigators.

This examine, “Impact of SGLT-2 inhibitors on physique composition in sufferers with sort 2 diabetes mellitus: A meta-analysis of randomized managed trials,“ was revealed in PLOS ONE.



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